A brief description of tissue optics, concept of ‘tissue optical windows’ and method of optical clearing (OC) based on controllable and reversible modification of tissue optical properties by their impregnation with a biocompatible optical clearing agent (OCA) will be done. Fundamentals and major mechanisms of OC allowing one to enhance optical imaging facilities and laser treatment efficiency of living tissues will be presented. The enhancement of probing/treatment depth and image contrast for a number of human and animal tissues investigated by using different optical modalities, including diffuse reflectance spectroscopy, collimated transmittance, OCT, photoacoustic microscopy, linear and nonlinear fluorescence, SHG and Raman microscopies will be discussed. Experimental data on the diffusion and permeability coefficients of biocompatible FDA approved OCAs, such as glucose, glycerol, PEG, albumin, CT contrast agents (Iohexol (OmnipaqueTM) and Iodixanol (VisipaqueTM)), and MRI contrast agents (Gadobutrol (GadovistTM)) in normal and pathological tissues (cancer and diabetes) will be presented. Perspectives of immersion optical clearing/contrasting technique aiming to enhance imaging of living tissues by using different imaging modalities working in the ultra-broad wavelength range will be discussed.

In my talk I am going to discuss some principle advantages which may be obtained with bright solitons for quantum metrology purposes. To be more specific I am focusing on matter-wave (Bose-Einstein condensate) solitons which can be used in this case. The linear and nonlinear metrology approaches will be discussed. I will show that bright quantum solitons provide a unique opportunity to achieve Super Heisenberg scaling (1/N^(3/2)) for phase estimation procedure even with coherent probes. I will show how further improvement of the phase estimation accuracy may be achieved by means of newly proposed soliton Josephson junction (SJJ) device, which consists of two weakly-coupled soliton-shape condensates. The formation of specific entangled Fock state superposition is predicted and examided in details for established quantum SJJ-model. We have shown that the obtained quantum state is more resistant to moderate particle losses in current metrological schemes with phase measurement and estimation.